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It’s a banner week for the end of the world, because we’ve officially pushed atmospheric carbon levels past their dreaded 400 parts per million. Permanently.

According to a blog post last Friday from the Scripps Institution of Oceanography, “it already seems safe to conclude that we won’t be seeing a monthly value below 400 ppm this year—or ever again for the indefinite future.” Their findings are based on weekly observations of carbon dioxide at Hawaii’s Mauna Loa Observatory, where climate scientists have been measuring CO2 levels since 1958.

What’s so terrifying about this number? For several years now, scientists have been warning us that if atmospheric carbon were allowed to surpass 400 parts per million, it would mark a serious “tipping point” into some unstoppable climate ramifications. In 2012, the Arctic was the first region on Earth to cross this red line. Three years later, for the first time since scientists had begun to record them, carbon levels remained above 400 parts per million for an entire month.

Chart: National Oceanic and Atmospheric Administration. Some description adapted from the Scripps CO2 Program website, “Keeling Curve Lessons.”

This time, experts believe we’re stuck here for good, due to the cyclical effects of Mauna Loa’s CO2 curve. Carbon levels usually reach an annual low point near the end of September, Scripps notes, but this year, those numbers are hovering around 401 parts per million. There’s a chance that we’ve haven’t seen 2016’s lowest carbon levels yet, but the institution deems that occurrence “almost impossible.”

If there’s an inkling of a silver lining here, it’s that scary numbers could scare people into action. For example, the Paris Agreement—an international convention dedicated to fighting climate change and its effects—has laid out some firm goals directly tied to carbon levels.

All countries who adopt the agreement are bound to prevent global average temperatures from rising above pre-industrial levels of 1.5°C. One of the primary means for achieving that will be to limit emissions, and enforce ambitious clean energy mandates. However, the 60 nations who have ratified the agreement so far only account for 47.76 percent of the world’s carbon emissions.

So in light of that, here are some of climate change’s other permanent effects, listed in no particular order.

Extinction

No explanation required here. While difficult to estimate, extinction rates have accelerated to 1,000 times their rate before the existence of modern Homo sapiens. The World Wildlife Fund guesses that 10,000 species become extinct every year. Due to climate change, one fourth of Earth’s species could vanish by 2050.

Food chain disruption

Inextricably tied to extinction, food chains are likely to become permanently unbalanced as apex predators and their prey begin to disappear. In the Arctic, for example, rising ocean temperatures are impacting the growth of sea algae, which in turn, deprives populations of zooplankton, cod, seals, and polar bears of vital nutrients. Over the last 50 years, average temperatures throughout Alaska and western Canada have risen by as much as 7°F.

Rising sea levels

In the near future, humans, among other species, will be catastrophically affected by sea level changes. As ancient glaciers begin to melt, coastlines elsewhere will flood, and communities will become displaced. By 2100, approximately 13 million people are projected to lose their homes due to rising sea levels. In some parts of the world, such as the Pacific Ocean, that’s already started to happen. Scientists theorize that even if we prevent global average temperatures from rising above 2°C, earlier sea level changes will still be irreversible.

Ocean acidification

Considered a crucial barometer of environmental health, ocean acidity is already wiping out entire marine ecosystems. The planet’s oceans are constantly absorbing excess CO2, causing their pH to decrease, literally acidifying the water. As a result, vast expanses of life-sustaining coral, such as Australia’s Great Barrier Reef, are bleaching and dying. While coral polyps could still take hold and regrow into reefs, scientists anticipate that bleaching events will leave long-lasting marks on the face of ocean ecosystems.

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